Revealing the enigmatic interplay between helicobacter pylori infection and biliary system diseases using Mendelian randomization analysis.

ABSTRACT: To date, evidence on the relationship between H. pylori infection and biliary diseases remains unclear. This Mendelian randomization (MR) study aim to investigate the causal relationship between H. pylori infection and various biliary system diseases. We obtained summary statistics for 7 hours. Pylori antibody levels and 5 biliary system diseases (cholelithiasis, cholecystitis, biliary system cancers, primary biliary cholangitis, and primary sclerosing cholangitis [PSC]) from public databases of different populations. The 2-sample bidirectional MR analysis was conducted using the Inverse-Variance Weighted (IVW) method, complemented by Bayesian Weighted MR. Heterogeneity analyses, tests for horizontal pleiotropy, and leave-one-out sensitivity analyses were performed to enhance the reliabili

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12419396 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature