Gastroesophageal reflux disease and risk of laryngeal cancer: A Mendelian randomization study.

ABSTRACT: While observational studies have identified associations between gastroesophageal reflux disease (GERD) and laryngeal cancer (LC), the causal direction remains undetermined. This study employed a bidirectional 2-sample Mendelian randomization (MR) approach complemented by meta-analysis to investigate potential causal relationships between GERD and LC. Analysis leveraged publicly accessible genome-wide association study resources. Instrumental variables meeting MR assumptions were rigorously selected. The inverse variance weighted method served as primary analysis, with horizontal pleiotropy assessed through MR-Egger intercept tests. Sensitivity evaluations included Cochran Q test for heterogeneity and leave-one-out analysis. Findings from multiple databases were consolidated via meta-analy

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12419439 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature