<b>Structural Defects Associated with Craniectomy Induce Neuroinflammation and Blood</b>-<b>Brain Barrier Permeability</b>.

ABSTRACT: Heterogeneity associated with traumatic brain injury (TBI) outcomes necessitates validated controls to differentiate pathophysiological events from experimental methodology. While craniectomies are commonly used in TBI research, inadvertent dura disruption can result in structural deficits, impacting cellular function and neurobehavioral outcomes. Thus, there is a critical need to evaluate the effect of craniectomy on neurological outcomes to develop robust experimental controls and improve pre-clinical TBI research. In this study, craniectomy mice undergoing surgical and anesthetic intervention were assessed against naïve mice for neurological deficits and pathophysiological dysfunction. T2-weighted magnetic resonance imaging confirmed that no lesions or cavities were observed postcraniec

SUBMITTER: Tarudji AW 

PROVIDER: S-EPMC12419447 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature