Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice.

ABSTRACT: Remembering familiar versus novel stimuli is fundamental to survival, but it is compromised in several neurodegenerative disorders where aging is a key factor. Although the components of the extracellular matrix (ECM) have been suggested to be implicated in memory maintenance, the mechanistic and behavioral roles of ECM during the aging process remain unclear. Here, we employed an accelerated mouse model of aging to elucidate the causal link between ECM dynamics and recognition memory during aging. Aged mice exhibited impaired social and non-social recognition memory, accompanied by increased intensity of perineuronal nets (PNNs), specialized ECM structures in the hippocampal dorsal CA2 (dCA2). A reduction in the power of theta oscillations (3-7 Hz) in the dCA2 of aged mice was also observ

SUBMITTER: Mehak SF 

PROVIDER: S-EPMC12419842 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature