A Frailty-Based Plasma Proteomic Signature Capturing Overall Health and Well-Being in Older Adults.

ABSTRACT: Frailty is an age-related syndrome characterized by an increased vulnerability to adverse health outcomes in the face of stressors. By deriving a blood-based proteomic signature for frailty, the current study aimed to enhance the understanding of frailty biology and created a person-specific predictor for the risk of frailty and other adverse age-related health outcomes. A 25-protein signature (proteomic frailty index [pFI]) predictive of the cumulative frailty index (FI) in the LonGenity cohort was derived using a penalized regression method. The pFI was significantly correlated with the FI at baseline (Pearson r = 0.58) and showed significant associations with age-related chronic conditions, incident mortality, and clinical measures. In an independent cohort of 5195 participants in the A

SUBMITTER: Sathyan S 

PROVIDER: S-EPMC12419846 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature