Naphthalene Metabolites From Long-Term Environmental Tobacco Smoke Induce the Aging of Retinal Pigment Epithelium.

ABSTRACT: Tobacco use is the main source of indoor air pollution and contains a variety of toxic components. The smoke from burning cigarettes is a key environmental risk factor that leads to accelerated aging and the occurrence of numerous diseases. Meanwhile, cigarette smoke and aging are both prominent risk factors for age-related macular degeneration (AMD). This study demonstrates that long-term exposure to cigarette smoke can impair retinal function and induce the aging of retinal pigment epithelium (RPE). Meanwhile, the plasma of rats after long-term exposure to cigarette smoke can trigger DNA damage and cellular senescence in vitro. In addition, naphthalene and its metabolites (1,2-dihydroxynaphthalene and 1,2-naphthoquinone) derived from cigarette smoke have been identified as an important f

SUBMITTER: Cui T 

PROVIDER: S-EPMC12419860 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature