Non-Surgical Periodontal Therapy Modulates Oral Microbiome in Primary Immunodeficient Children.

ABSTRACT:

Background and aim

Primary Immunodeficiencies (PIDs) arise from rare genetic defects affecting humoral and cellular immunity, which can lead to reduced dental plaque control. This study aimed to characterise the subgingival dental plaque microbiome in neutropenic PID children compared to healthy controls and assess their response to non-surgical periodontal therapy.

Methods

Subgingival plaque was collected from three first molars and one first incisor at baseline and 6 months post therapy from children with PID (n = 24) and systematically healthy control participants (n = 24) who were recruited from Great Ormond Street Hospital and Barts Health NHS Trust, respectively. The subgingival microbiome was profiled using an Illumina metabarcoding approach on the bacterial 16S rRNA

SUBMITTER: Stephen AS 

PROVIDER: S-EPMC12420080 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature