Association between sensitivity to thyroid hormone and prognosis in septic patients: a retrospective cohort analysis.

ABSTRACT:

Purpose

Sepsis is associated with significant endocrine dysfunction, particularly in thyroid hormone metabolism. This study aims to investigate the association between thyroid hormone sensitivity indices and prognosis in sepsis, exploring their potential as early prognostic markers.

Methods

We conducted a retrospective analysis of sepsis patients admitted to the Affiliated Hospital of Guangdong Medical University. Nonlinear associations between thyroid hormones (FT3, FT4, TSH), sensitivity indices (FT3/FT4, TFQI, PTFQI, TSHI, TT4RI), and sepsis mortality were assessed using restricted cubic spline models. Kaplan-Meier curves along with Cox proportional hazards models were used to investigate the longitudinal associations. K-means clustering was applied to thyroid hormone pro

SUBMITTER: Wang J 

PROVIDER: S-EPMC12420208 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature