Effect of co-vaccination of cattle with RB51 and BCG on vaccine-specific CD4⁺ T cell responses.

ABSTRACT:

Introduction

Brucella abortus and Mycobacterium bovis, the causative agents of bovine brucellosis and tuberculosis respectively, are zoonotic bacterial pathogens that both contribute to major economic losses in the cattle industry and pose a human health risk worldwide. Co-infections of cattle with B. abortus and M. bovis have been identified in various developing countries, necessitating the development of an efficacious strategy for controlling both important zoonotic diseases even in the event of co-infection. Brucella abortus strain RB51, a live attenuated vaccine for bovine brucellosis that is currently used in the US, is highly effective at preventing reproductive failure due to brucellosis in cattle. Bacillus Calmette-Guérin (BCG) is a live

SUBMITTER: Sterle HM 

PROVIDER: S-EPMC12420227 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature