Large-scale statistical mapping of T-cell receptor <i>β</i> sequences to human leukocyte antigens.

ABSTRACT:

Introduction

T-cell receptors (TCRs) interacting with peptides presented by human leukocyte antigens (HLAs) are the foundation of the adaptive immune system, but population-level analysis of TCR-HLA interactions is lacking.

Methods

We statistically associated approximately 10⁶ public TCRβs to specific HLAs using TCRβ repertoires sampled from 4,144 HLA-genotyped subjects. The TCRβs we associated were specific to unique HLA allotypes, not allelic groups, and to the paired α-β heterodimer of class II HLAs, though exceptions were observed.

Results

This specificity permitted highly accurate imputation of 248 class I and II HLAs from the TCRβ repertoire. Notably, 45 HLA-DP and -DQ heterodimers lacked associated TCRs because they likely arise from non-functional t

SUBMITTER: Zahid HJ 

PROVIDER: S-EPMC12420235 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature