Shared immune-inflammatory mechanisms between ulcerative colitis and periodontitis: a multi-omics analysis.

ABSTRACT:

Background

Ulcerative colitis (UC) and periodontitis (PD) are chronic inflammatory diseases with increasing evidence of bidirectional communication through the oral-gut axis. However, the immunological mechanisms underlying their co-occurrence remain largely unclear.

Methods

We conducted a bidirectional Mendelian randomization (MR) analysis to evaluate potential causal relationships between UC and PD. Transcriptomic data from public repositories were integrated to identify shared differentially expressed genes. Immune-related genes were further screened using three machine learning approaches. Enrichment analysis and immune cell infiltration profiling were performed to explore underlying mechanisms. A rat model combining UC and PD was established to validate key findings

SUBMITTER: Li H 

PROVIDER: S-EPMC12420251 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature