High humidity environment increases FBG by impairing the intestinal barrier.

ABSTRACT:

Introduction

Climate and environmental changes pose significant threats to human metabolic health; however, the specific effects of individual environmental factors on metabolic diseases remain poorly understood. This study aimed to investigate the impact of a high humidity environment (HH) on fasting blood glucose (FBG), intestinal barrier integrity, and gut microbiota composition.

Methods

We analyzed clinical samples collected during HH exposure and performed a controlled male mouse experiment. FBG and hormone levels were assessed, and intestinal barrier integrity was evaluated using western blot and immunofluorescence staining. Gut microbiota composition was profiled via 16S rDNA sequencing. Mechanistic insights were obtained through fecal microbiota transplantation (FMT)

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12420254 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature