Innate immune dysfunction and persistent activation in South African HIV elite controllers.

ABSTRACT:

Background

Elite controllers can spontaneously control HIV-1 infection without antiretroviral treatment but remain at risk of developing non-AIDS-related conditions. The adaptive immune system is key in mediating spontaneous viral control; however, the innate immune response remains understudied. We assessed the quality of the innate immune responses by evaluating the phenotype and function of antigen-presenting cells (APCs) in South African adults living with HIV (PWH).

Methodology

A total of 73 black South Africans were included in this study. Of these, 55 were living with HIV and included 16 individuals with spontaneous viral control (PWH_EC), 20 HIV progressors (PWH_PROG), and 19 individuals suppressed on ART (PWH_ART). Eighteen individuals

SUBMITTER: Mohamed A 

PROVIDER: S-EPMC12420260 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature