A rapid antigen test to detect adenosine deaminase 2 (ADA2) in biological fluids and its application in clinical diagnostics.

ABSTRACT:

Introduction

Saliva biomarkers provide a convenient and noninvasive method for diagnosing immune and genetic disorders. One such biomarker is adenosine deaminase 2 (ADA2), an enzyme that converts adenosine into inosine and is elevated in cancer and immune diseases. Currently, ADA2 activity can be used to diagnose pleural tuberculosis. Recently, we developed an ELISA assay that detects ADA2 in saliva. This test has been successfully employed to diagnose adenosine deaminase 2 deficiency (DADA2) and potentially to identify individuals with head and neck cancer. DADA2 is a rare genetic disease that can lead to systemic vasculitis, early onset stroke, bone marrow failure, and/or immunodeficiency. A rapid, simple, and affordable point-of-care (POC) test would significantly aid in diagnos

SUBMITTER: Yang W 

PROVIDER: S-EPMC12420330 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature