<i>miR-628-3p</i> exerts a carcinogenic effect on hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is associated with the highest mortality rate among various types of liver tumors. miR-628-3p, a microRNA, has been identified as a tumor suppressor in multiple cancer types, yet its function in hepatocellular carcinoma has not been investigated. This study aimed to examine the effect of miR-628-3p on the occurrence and development of HCC and its specific molecular mechanism. Here, we evaluated the effect of miR-628-3p on HCC proliferation by using in vitro proliferation assays and a xenograft tumor model. Flow cytometry was used to monitor the cell cycle and apoptosis of HCC cells. Reverse Transcription-Quantitative Polymerase Chain Reaction (RT-qPCR) and Western blot (WB) were used to determine the expression of each gene. Our st

SUBMITTER: Liu L 

PROVIDER: S-EPMC12420519 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature