The concept, intention, and evaluation of the term treatment-refractory meningioma.

ABSTRACT:

Background

Treatment-refractory meningioma is a widely used term but lacks standardized criteria, impairing research comparability and treatment evaluation. The aim of this study was to assess the heterogeneity of patient populations labeled as treatment-refractory and to explore recommendations for better consistency.

Methods

We systematically reviewed 69 studies published before 2024 and analyzed individual participant data from 15 cohorts (n = 211) that included treatment-refractory patients who underwent experimental therapy with somatostatin receptor (SSTR)-targeted therapies. A reference cohort (n = 102) with newly diagnosed WHO-3 meningiomas was used descriptively for comparison. Progression and death were the primary endpoints. Hazard rate ratios were estimated via P

SUBMITTER: Jensen LR 

PROVIDER: S-EPMC12420741 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature