Liver steatosis mediates the association between metabolic score for insulin resistance and obstructive sleep apnea.

ABSTRACT: Obstructive sleep apnea (OSA) is associated with metabolic disorders such as insulin resistance and liver fat accumulation. However, the specific mediating role of liver-related metabolic indicators in this association has not been fully studied. The purpose of this study was to investigate the relationship between Metabolic Score for Insulin Resistance (METS-IR) and OSA, focusing on the mediating effects of liver fat percentage (PLF) and hepatic steatosis index (HSI). Understanding these mechanisms may provide insights into targeted interventions for OSA. A total of 12,655 participants from the National Health and Nutrition Examination Survey (NHANES) were included in this analysis. Obstructive sleep apnea (OSA) was assessed using the NHANES questionnaire. Weighted multivariate logistic r

SUBMITTER: Song S 

PROVIDER: S-EPMC12420785 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature