Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers.

ABSTRACT: Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor strongly associated with exposure to tobacco carcinogens, is characterized by early dissemination and dismal prognosis with a five-year overall survival of less than 7%. High-frequency gain-of-function mutations in oncogenes are rarely reported, and intratumor heterogeneity (ITH) remains to be determined in SCLC. Here, via multiomics analyses of 314 SCLCs, we found that the ASCL1⁺/MKI67⁺ and ASCL1⁺/CRIP2⁺ clusters accounted for 74.38% of the 190,313 SCLC cancer cells from 39 patients, with the ASCL1⁺SOX1⁺ stem-like cell cluster across SCLC subtypes. The major histocompatibility complex (MHC) class I molecules were expressed at low levels in six and high levels

SUBMITTER: Wang GZ 

PROVIDER: S-EPMC12420805 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature