Contrasting contribution of resident and repopulated brain macrophages in sustaining sleep-wake circuitry.

ABSTRACT: Sleep is a complex behavior regulated by various brain cell types. However, the roles of brain-resident macrophages, including microglia and CNS-associated macrophages (CAMs), particularly those derived postnatally, in sleep regulation remain poorly understood. Here, we investigated the effects of resident (embryo-derived) and repopulated (postnatally derived) brain-resident macrophages on the regulation of vigilance states in mice. We found that depletion in resident brain macrophages caused increased sleep in the active period, but reduced its quality, reflected in reduced power of brain sleep oscillations. This was observed both for the Non-REM and REM sleep stages. Subsequent repopulation by postnatal brain macrophages resulted in altered, but not fully restored, sleep-wake patterns an

SUBMITTER: Seifinejad A 

PROVIDER: S-EPMC12420833 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature