Paediatric Traumatic Brain Injury and Long-Term Antidepressant Use: A Nationwide Register-Based Cohort Study.

ABSTRACT:

Aim

The association between paediatric traumatic brain injury (pTBI) and post-traumatic antidepressant medication usage remains an understudied subject.

Methods

A nationwide Finnish retrospective cohort study (1998-2018) included 71 969 pTBI patients and 64 856 orthopaedic references. Antidepressant medication data were sourced from the Finnish Social Insurance Institution. The primary outcome was post-traumatic paediatric antidepressant use.

Results

The study included 136 825 patients. Kaplan-Meier analyses showed higher antidepressant use in pTBI patients, especially after 5 years and following surgery. The cumulative incidence rate (CIR) after 1 year was 0.73% (pTBI) versus 0.34% (references), increasing to 26.95% versus 25.51% after 20 years. Cox regression showed

SUBMITTER: Laaksonen J 

PROVIDER: S-EPMC12420842 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature