Longitudinal quantification of serum SARS-CoV-2 neutralising antibodies, pro-inflammatory cytokines, NfL and GFAP before and after breakthrough COVID-19 infection in CNS neuroimmunological diseases: a prospective observational study.

ABSTRACT:

Background

Immunosuppressive treatment can attenuate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced immune responses. Moreover, SARS-CoV-2 has neuroinvasive potential and may induce a persistent pro-inflammatory milieu following infection.

Objectives

To investigate if diminished post-vaccine humoral responses can be overcome with additional vaccine doses and/or breakthrough COVID-19 infections, and if COVID-19 infection can lead to a pro-inflammatory state with neuroaxonal/neuroglial injury in the intermediate-term in patients with central nervous system (CNS) neuroimmunological diseases.

Design

A prospective observational study conducted at National Neuroscience Institute, Singapore.

Methods

Serum levels of SARS-CoV-2 neutralising

SUBMITTER: Hema Prashaad M 

PROVIDER: S-EPMC12420963 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature