Superior vena cava isolation added to pulmonary vein isolation enhances outcomes in paroxysmal atrial fibrillation: a meta-analysis with trial sequential analysis.

ABSTRACT:

Objectives

To evaluate the efficacy and safety of adding Superior Vena Cava Isolation (SVCI) to Pulmonary Vein Isolation (PVI) in patients with drug-refractory paroxysmal atrial fibrillation (PAF).

Design

Systematic review and meta-analysis of randomised controlled trials (RCTs) using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, supplemented with Trial Sequential Analysis (TSA) to assess evidence sufficiency.

Data sources

We searched PubMed, EMBASE, the Cochrane Library (CENTRAL) and Web of Science for relevant studies published up to 13 July 2025.

Eligibility criteria

We included prospective RCTs comparing SVCI+PVI versus PVI alone in adults with drug-refractory PAF, with at least 3 months of follow-up and reporting

SUBMITTER: Guan W 

PROVIDER: S-EPMC12421151 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature