Anticancer properties of propofol-docosahexaenoate and propofol-eicosapentaenoate on breast cancer cells.

ABSTRACT:

Introduction

Epidemiological evidence strongly links fish oil, which is rich in docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), with low incidences of several types of cancer. The inhibitory effects of omega-3 polyunsaturated fatty acids on cancer development and progression are supported by studies with cultured cells and animal models. Propofol (2,6-diisopropylphenol) is the most extensively used general anesthetic-sedative agent employed today and is nontoxic to humans at high levels (50 microg/ml). Clinically relevant concentrations of propofol (3 to 8 microg/ml; 20 to 50 microM) have also been reported to have anticancer activities. The present study describes the synthesis, purification, characterization and evaluation of two novel anticancer conjugates, propofol-

SUBMITTER: Siddiqui RA 

PROVIDER: S-EPMC1242121 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature