Fish Acellular Dermal Matrix Promotes Repair of Full-Thickness Skin Defects in Mice and Bama Pigs.

ABSTRACT: This study aimed to develop an acellular dermal matrix derived from tilapia skin and evaluate its potential as a bioscaffold for skin wound repair. Structural and compositional changes before and after decellularisation were assessed through histological staining, electron microscopy and immunological analysis. The matrix exhibited low immunogenicity, preserved extracellular matrix architecture and retained key bioactive components. In vitro, the matrix significantly promoted cell proliferation, migration, and tube formation in human umbilical vein endothelial cells and human foreskin fibroblasts. In vivo, full-thickness skin defect models in Balb/c mice and Bama pigs demonstrated that the tilapia-derived matrix not only accelerated wound closure but also improved the quality of tissue reg

SUBMITTER: Wang ZY 

PROVIDER: S-EPMC12421219 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature