Development and characterization of a prototype selenium-75 high dose rate brachytherapy source.

ABSTRACT:

Background

⁷⁵Se ( t1/2$t_{1/2}$ ≈$\approx$ 120 days, Eγ,avg$E_{\gamma,\text{avg}}$ ≈$\approx$ 215 keV) offers advantages over ¹⁹²Ir ( t1/2$t_{1/2}$ ≈$\approx$ 74 days, Eγ,avg$E_{\gamma,\text{avg}}$ ≈$\approx$ 360 keV) as a high dose rate brachytherapy source due to its lower gamma energy and longer half-life. Despite its widespread use in industrial gamma radiography, a ⁷⁵Se brachytherapy source has yet to be manufactured.

Purpose

A novel ⁷⁵Se-based source design with a vanadium diselenide core, titled the SeCure source, was proposed. This study aimed to evaluate the feasibility of this source design for dosimetry and manufacturability purposes and to develop an activated prototype source.

Methods

The source was modeled and

SUBMITTER: Kalinowski J 

PROVIDER: S-EPMC12421221 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature