Corneal stromal microdots accumulation and its association with corneal neurodegeneration and retinal microvascular perfusion in diabetes.

ABSTRACT:

Purpose

The purpose of the study was to investigate the deposition of microdots in corneal stroma in diabetes mellitus (DM) patients and assess the relationship between microdots and corneal nerve damage as well as retinal microvascular perfusion.

Methods

127 patients with DM and 36 age and sex-matched controls were included. All subjects were examined by in vivo confocal microscopy (IVCM) and optical coherence tomography angiography (OCTA). Histochemistry staining was also performed in cadaver corneas from patients with DM or control subjects.

Results

The deposition of microdots was significantly increased in corneal stroma in patients with DM than controls (P<0.0001). Spearman's rank correlation showed that the deposition of microdots in subepithelial,

SUBMITTER: Wang J 

PROVIDER: S-EPMC12421287 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature