Causal Association of Plasma Lipidome With Inflammatory Bowel Diseases and Mediating Role of Circulating Inflammatory Proteins: A Mendelian Randomization Study.

ABSTRACT: The existing studies indicate that the lipidome may be associated with inflammatory bowel disease (IBD). However, most of the results of previous studies are based on epidemiological or observational studies. Meanwhile, the causal association between different lipids and inflammatory bowel diseases, as well as whether inflammatory proteins act as mediators, remains unclear. We employed Mendelian randomized (MR) analysis to investigate the causal relationship between lipidome and IBD (ulcerative colitis and Crohn's disease). We mainly used the IVW method for MR analysis and further evaluated heterogeneity and pleiotropy. Additionally, we explored whether circulating inflammatory proteins play a mediating role in the pathway from the lipidome to IBD. In our MR study, we identified causal rel

SUBMITTER: Yin L 

PROVIDER: S-EPMC12421312 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature