Histologic Chorioamnionitis and Neurodevelopment in Preterm Infants.

ABSTRACT:

Importance

Exposure to inflammation from chorioamnionitis places the fetus at higher risk of premature birth and may increase the risk of neurodevelopmental impairments, though the evidence for the latter is mixed.

Objective

To evaluate whether moderate to severe histologic chorioamnionitis (HCA) is directly associated with adverse motor performance, independent of the indirect mediating effects of premature birth.

Design, setting, and participants

This prospective, population-based cohort study recruited participants between September 16, 2016, and November 19, 2019, from referral and nonreferral neonatal intensive care units of 5 southwestern Ohio hospitals. Preterm infants of gestational age (GA) 32 weeks or younger were consecutively enrolled. The data were analyz

SUBMITTER: Peterson LS 

PROVIDER: S-EPMC12421339 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature