Abnormal Amyloid-β Duration, Tau, and Neurodegeneration in Cranial Images.

ABSTRACT:

Importance

It is unclear whether the duration of amyloid-β (Aβ) pathology is associated with neurodegeneration and whether this depends on the presence of tau.

Objective

To examine the association of longitudinal atrophy with Aβ positron emission tomography (PET)-positivity (Aβ+) and the estimated duration of Aβ+ (Aβ+ duration), controlling for tau-positivity.

Design, setting, and participants

Data for this longitudinal cohort study were drawn from the Wisconsin Registry for Alzheimer Prevention and the Wisconsin Alzheimer Disease Research Center Clinical Core Study. Participants who had 2 or more magnetic resonance imaging (MRI) visits, 1 Pittsburgh compound B (PiB) PET visit, and 1 MK-6240 PET visit with other covariates available were included. A replication analys

SUBMITTER: Stephenson HG 

PROVIDER: S-EPMC12421349 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature