Prognostic significance of prognostic nutritional index in patients with head and neck squamous cell carcinoma.

ABSTRACT:

Objective

This study aimed to investigate the relationship between prognostic nutritional index (PNI) and prognosis in patients with head and neck squamous cell carcinoma (HNSCC).

Methods

A systematic review was conducted across three major databases-Embase, PubMed, and the Cochrane Library-to identify studies examining the association between PNI and outcomes in HNSCC patients. The search included all records from database inception through January 20, 2025. Outcomes assessed included hazard ratios (HRs) for overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS), and progression-free survival (PFS), as well as odds ratios (ORs) for objective response rate (ORR) and disease control rate (DCR).

Results

A total of 27 articles involving 4,400

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12421403 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature