CHDH Promotes Breast Cancer Metastasis Relying on IL17RB/CREB1 Signalling Activation.

ABSTRACT: The involvement of Choline Dehydrogenase (CHDH) in metabolic disorders and tumour progression has garnered significant scholarly interest. However, the specific role of CHDH in the metastasis and progression of breast cancer (BC) has been less thoroughly investigated. Our research indicates that CHDH protein expression is markedly elevated in breast cancer tissues compared to normal tissues, and this expression is positively correlated with the tumour node metastasis (TNM) stage of breast cancer. Furthermore, CHDH levels were found to be significantly higher in breast cancer cell lines relative to normal breast cells. The silencing of CHDH expression resulted in a reduction of breast cancer cell migration, while the overexpression of CHDH facilitated increased migration and tumour metastas

SUBMITTER: Li Y 

PROVIDER: S-EPMC12421421 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature