The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling.

ABSTRACT:

Background and purpose

Fibrotic lung remodelling after a respiratory viral infection represents a debilitating clinical sequela. Studying or managing viral-fibrotic sequela remains challenging, due to limited therapeutic options and lack of understanding of mechanisms. This study determined whether protein disulfide isomerase A3 (PDIA3) and secreted phosphoprotein 1 (SPP1), which are associated with pulmonary fibrosis, can promote influenza-induced lung fibrotic remodelling and whether inhibition of PDIA3 or SPP1 can resolve viral-mediated fibrotic remodelling.

Experimental approach

A retrospective analysis of TriNetX data sets was conducted. Serum from healthy controls and influenza A virus (IAV)-infected patients was analysed. An inhibitor of PDIA3, punicalagin, and a neut

SUBMITTER: Kumar A 

PROVIDER: S-EPMC12421427 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature