Long-term exposure to ambient air pollutant and acute exacerbations of chronic obstructive pulmonary disease: a retrospective cohort study in Xinjiang, China.

ABSTRACT:

Introduction

While short-term ambient air pollution is implicated in chronic obstructive pulmonary disease (COPD) exacerbations, evidence for chronic exposure remains limited, particularly in vulnerable subgroups. This study evaluates longitudinal associations between major air pollutants and acute exacerbations (AEs), while identifying high-risk demographic and clinical subgroups.

Methods

We analyzed 660 COPD patients from People's Hospital of Xinjiang (2020-2023). Annual average concentrations of PM_2.5, PM₁₀, O₃, NO₂, SO₂, and CO were geocoded to residential addresses. Single-pollutant logistic regression models adjusted for 12 clinical/sociodemographic confounders assessed AE risks, with robustness verified by two-pol

SUBMITTER: Lian Z 

PROVIDER: S-EPMC12421444 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature