Clinical Characteristics and Disease Burden of Wheat Allergy Dependent on Augmentation Factors in Recreationally Active and Trained Individuals.

ABSTRACT: In wheat allergy dependent on augmentation factors (WALDA), allergic reactions occur when wheat ingestion is combined with exercise or rarely other augmentation factors. We analyzed clinical characteristics and disease burden in recreationally active and trained individuals with WALDA diagnosed by oral challenge test. Clinical characteristics, serological data, and quality of life (QOL) questionnaires were analyzed and completed with follow-up interviews. Twenty recreationally active and trained WALDA patients (five female, 15 male; median age 45 years; median exercise frequency 3.5 times weekly) participated. All had experienced allergic reactions during or after different types of exercise-predominantly endurance activities-and 85% developed systemic anaphylaxis. Diagnosis was delayed by

SUBMITTER: Faihs V 

PROVIDER: S-EPMC12421479 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature