Multifunctional Tannic Acid and Polyamino Acid Layer-by-Layer Coatings for Tailored Implant Surfaces.

ABSTRACT: Polyphenols are attractive candidates for biological surface modifications due to their adhesive, antioxidant, anti-inflammatory, and antimicrobial properties. However, the uncontrolled release of polyphenols, such as tannic acid (TA), from the surface may lead to adverse biological responses. Polyamino acids (PAAs), such as poly-l-lysine (PLL) and poly-l-arginine (PLR), improve wound healing and act as antimicrobial agents, but their high positive charge can result in cytotoxicity. In this study, TA and PAAs were combined in layer-by-layer (LbL) coatings to take advantage of the beneficial biological properties of these molecules while limiting their release and the potential damage they can cause to the surrounding tissues. Coating formation was monitored using a quartz crystal microbala

SUBMITTER: Oreja E 

PROVIDER: S-EPMC12421510 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature