Toward Sex-Specific Biomaterials Innovation: A Perspective.

ABSTRACT: Sex-related differences influence key biological processes relevant to biomaterials research, including tissue regeneration, immune response, drug metabolism, and relevant diseases. Despite increasing recognition of sex as a critical biological variable, biomaterials research has historically relied on generalized study designs that fail to account for sex-specific physiological variability. This oversight has contributed to inconsistencies in biomaterial performance, reduced predictive accuracy in preclinical studies, and increased the risk of suboptimal clinical outcomes. A transition toward sex-specific biomaterials research is necessary to advance precision medicine and ensure that biomaterials are designed to perform optimally across different patient populations. This perspective exa

SUBMITTER: Koons GL 

PROVIDER: S-EPMC12421524 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature