Oxidized Phospholipids on Apo B₁₀₀, Platelet Activation and Reactivity, and Long-Term Cardiovascular Outcomes.

ABSTRACT:

Background

OxPL-apoB (oxidized phospholipids [OxPL] on apo B₁₀₀), which include OxPL present on Lp(a) (lipoprotein [a]), are associated with higher cardiovascular risk. Experimental studies suggest that OxPL may influence platelet function.

Methods

This observational study assessed the association of OxPL-apoB with intrinsic and on‑clopidogrel platelet reactivity and long-term cardiovascular events in patients undergoing coronary angiography with or without percutaneous coronary intervention in 2040 patients in the EXCELSIOR trial (Impact of Extent of Clopidogrel-Induced Platelet Inhibition During Elective Stent Implantation on Clinical Event Rate). The association of OxPL-apoB to expression of CD62P, CD41, or PAC-1 levels and intrinsic and on-clopidogrel platelet

SUBMITTER: Tsimikas S 

PROVIDER: S-EPMC12421647 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature