Electrospun Polymer Fiber Mats for Persulfide Prodrug Delivery.

ABSTRACT: Persulfides (RSSH) and hydrogen sulfide (H₂S) are endogenously produced bioactive molecules that serve important roles in vasculogenesis and tissue repair processes. Through the physical incorporation of RSSH/H₂S donors into electrospun fibers, we designed polymeric fiber mats that released provasculogenic and cytoprotective reactive sulfur species over biologically relevant time scales. The release of small molecules from the fiber mats showed that 20-50% of the analytes were released from the scaffolds after 4 h. Tube formation assays indicated that the persulfide donors improved tube formation in human microvascular endothelial cells (HMVECs) over baseline levels under oxidative conditions (H₂O₂). Analysis of HMVECs on the electrospun fiber ma

SUBMITTER: Swilley SN 

PROVIDER: S-EPMC12421669 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature