Davanat-Mimetic Galactomannan and Its Sulfated Derivative: Structure and Antitumor Effects against Melanoma.

ABSTRACT: Melanoma is the most aggressive skin cancer, with a high metastatic potential and limited treatment options in advanced stages. Polysaccharides are promising antitumor agents, and therefore, this study investigated a galactomannan from guar gum hydrolysis (GGH) and its sulfated derivative (GGHS) for their antimelanoma and immunostimulatory effects. GGH shares structural similarity with DAVANAT, a galectin-1 ligand with anticolorectal cancer activity, while GGHS has anticoagulant properties, like heparin used in cancer patients. In vitro, 100 μg/mL GGH or GGHS inhibited melanoma cell invasion, increased adhesion, and reduced colony size, while GGHS also reduced proliferation. Both compounds bind galectin-3 and -1, but only GGH suppressed tumor progression in mice. Both treatments sti

SUBMITTER: Junior OB 

PROVIDER: S-EPMC12421689 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature