Sex-specific association of novel complex inflammatory markers with colorectal polyps: mediating effects of triglyceride-glucose and non-high-density lipoprotein cholesterol.

ABSTRACT:

Background

The CRP-albumin-lymphocyte (CALLY) index has potential clinical value as a novel marker integrating inflammatory, nutritional and immune status in the development of colorectal polyps. This study examined whether gender factors influence the association between CALLY and colorectal polyps; in addition to elucidating whether metabolic pathways mediate this relationship.

Methods

This is a cross-sectional study including 5409 adult health screening participants who completed colonoscopy. Logistic regression analysis, correlation analysis, linear regression analysis and restricted cubic spline modeling, and mediation analysis were employed to investigate the intricate associations between CALLY index, inflammatory biomarkers, metabolic factors and colorectal polyps.

SUBMITTER: Li M 

PROVIDER: S-EPMC12421735 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature