The systematic assessment of completeness of public metadata accompanying omics studies in the Gene Expression Omnibus data repository.

ABSTRACT:

Background

Recent advances in high-throughput sequencing technologies have enabled the collection and sharing of a massive amount of omics data, along with its associated metadata-descriptive information that contextualizes the data, including phenotypic traits and experimental design. Enhancing metadata availability is critical to ensure data reusability and reproducibility and to facilitate novel biomedical discoveries through effective data reuse. Yet, incomplete metadata accompanying public omics data may hinder reproducibility and reusability and limit secondary analyses.

Results

Our study assesses the completeness of metadata in over 253 scientific studies, covering more than 164,000 samples from both human and non-human mammalian studies. We find that over 25% of crit

SUBMITTER: Huang YN 

PROVIDER: S-EPMC12421755 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature