Single-cell atlas in the living fossil Yangtze sturgeon provides insight into the evolution of fish.

ABSTRACT:

Background

Fish are the largest group of vertebrates. Studying the characteristics, functions, and interactions of different fish cells is important for understanding their roles in disease and evolution. However, most single cell RNA-seq studies in fish are restricted to a few specific organs, leaving a comprehensive cell landscape that aims to characterize the heterogeneity and connections among body-wide organs largely unexplored.

Results

We construct a single-cell atlas from the Yangtze sturgeon, Acipenser dabryanus, containing 82,401 high-quality cells and identify 72 major cell types. We compare differentially expressed genes among enterocytes in each part of the intestines and reveal the differences in absorption function of pyloric caecum, duodenum, spiral intestine,

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12421772 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature