C-di-GMP regulates bacterial NAD biosynthesis via targeting the transcriptional repressor NadR.

ABSTRACT: As a near-ubiquitous bacterial second messenger, cyclic di-GMP (c-di-GMP) regulates a multitude of important biological processes. The regulatory effects of c-di-GMP on bacterial physiological processes are mediated through its interaction with various effector molecules, including mRNA riboswitches and proteins. Although c-di-GMP effector proteins have been widely reported, yet unknown c-di-GMP effectors in bacteria wait to be discovered, and the physiological roles of this second messenger still remain to be explored. In a c-di-GMP/transcription factor binding screen, we identified NadR, a repressor of nicotinamide adenine dinucleotide (NAD) synthesis and salvage, as a c-di-GMP-responsive transcription factor in Salmonella enterica serovar Typhimurium. c-di-GMP was found to bind t

SUBMITTER: Mao L 

PROVIDER: S-EPMC12421817 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature