Redox control of antibiotic biosynthesis.

ABSTRACT: Streptomyces bacteria make diverse specialized metabolites that form the basis of ~55% of clinically used antibiotics. Despite this, only 3% of their encoded specialized metabolites have been matched to molecules, and understanding how their biosynthesis is controlled is essential to fully exploit their potential. Here, we use Streptomyces formicae and the formicamycin biosynthetic pathway as a model to understand the complex regulation of specialized metabolism. We analyzed all three pathway-specific regulators and found that biosynthesis is subject to negative feedback and redox control via two MarR-family proteins, while activation of the pathway is dependent on a cytoplasmic two-component system. Like many Streptomyces antibiotics, formicamycins are only produced i

SUBMITTER: Devine R 

PROVIDER: S-EPMC12421854 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature