ABCF protein-mediated resistance shapes bacterial responses to antibiotics based on their type and concentration.

ABSTRACT: ABCF-ATPases are increasingly recognized as translation factors that rescue stalled ribosomes when they encounter difficult mRNA templates or are stalled by antibiotics. The latter defines antibiotic resistance ABCF (ARE ABCF) proteins, known for their role in antibiotic resistance. However, in this study, we reveal a broader role of ARE ABCFs in antibiotic-responsive regulation. Using genetic, OMICs, and biochemical approaches, we showed that ARE ABCF proteins TiaA and Are5sc in Streptomyces coelicolor use their resistance functions to modulate specialized metabolism and proteosynthesis in response to lincosamide, streptogramin A, and pleuromutilin (LS_AP) antibiotics. Although under LS_AP exposure, either Are5sc or TiaA is essential for activating the biosynthe

SUBMITTER: Koberska M 

PROVIDER: S-EPMC12421871 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature