Disrupting NtrC function reveals unexpected robustness in a central cell cycle regulatory network.

ABSTRACT: Cell cycle progression relies on coordinated signaling systems that integrate diverse cellular and environmental cues. In Caulobacter and related Alphaproteobacteria, the essential sensor histidine kinase CckA initiates a phosphorelay signaling cascade that controls both the transcriptional activity and proteolytic stability of the master cell cycle regulator, CtrA. To uncover regulatory connections between this essential Caulobacter signaling pathway and other cellular processes, we selected for mutations that bypassed the loss of CckA function. Among the identified mutations were structurally distinct loss-of-function alleles of the conserved nitrogen assimilation regulator ntrC, which differentially suppressed the viability defect of a temperature-sensitive (ts)

SUBMITTER: North H 

PROVIDER: S-EPMC12421884 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature