Fungal-fungal cocultivation alters secondary metabolites of marine fungi mediated by reactive oxygen species (ROS).

ABSTRACT: Microorganisms form complex ecological networks of interactions, with secondary metabolites (SMs) playing a crucial role in microbial communication. This study explored the cocultivation of marine fungi Alternaria alternata and Nigrospora sphaerica, uncovering significant SM production changes. The biosynthetic gene clusters (BGCs) and transcription factor aohR in marine A. alternata were activated, leading to enhanced production of alternariol (AOH), a compound inhibiting fungal competitors, whereas the activation was not present in the coculture of terrestrial strains of A. alternata. Transcriptomic and metabolic analyses further revealed that reactive oxygen species (ROS) play a crucial role as signaling molecules in these marine fungal interactions. E

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC12421890 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature