Siderophore systems at play: system interactions as drivers of diversification in pathogenic <i>Vibrio</i>.

ABSTRACT: The irp-HPI genomic island encodes the salicylate-type siderophore piscibactin, a key virulence factor in several pathogenic Vibrio species. To advance our understanding of the siderophore metabolome (siderome) in Vibrio anguillarum, we combined high-resolution metabolomics with genetic and phenotypic analyses of biosynthetic mutants. LC-MS/MS and Feature-Based Molecular Networking (FBMN) revealed the presence of known siderophores, vanchrobactin and piscibactin/photoxenobactin-like siderophores, alongside two non-reported catecholate analogs of the formed siderophores, 2-hydroxypiscibactin (2-OH-Pcb) and 2-hydroxyphotoxenobactin E (2-OH-PxbE). Functional characterization of mutants defective in piscibactin or vanchrobactin production demonstrated biosynthetic and upta

SUBMITTER: Lages MA 

PROVIDER: S-EPMC12421891 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature