Antibiotics and phages drive region-specific diversity of OmpK36 in <i>Klebsiella pneumoniae</i>.

ABSTRACT: The Enterobacterales outer membrane is impermeable to many antibiotics, but they can enter the cell via channel proteins, called porins. In Klebsiella pneumoniae, the porin OmpK36 is a major determinant of antibiotic resistance. Insertion of amino acids into the L3 constriction loop is frequently reported, leading to decreased channel size and reduced antibiotic susceptibility. While the involvement of the L3 loop in resistance is well-established, studies focused on a limited number of sequences, without considering any role for diversity outside L3. To fill this gap, we carried out a large-scale genomic comparison combined with experimental analysis. We analyzed 16,086 K. pneumoniae genomes to decipher the diversity of OmpK36 at the species level. We identifie

SUBMITTER: Royer G 

PROVIDER: S-EPMC12421954 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature