<i>Plasmodium falciparum</i> PP1 phosphatase is a key regulator of malaria parasite transmission.

ABSTRACT: For the successful transmission of malaria parasites from humans to mosquitoes, Plasmodium falciparum gametocytes must remain in the bloodstream long enough to be taken up by a mosquito. Once ingested, they are then activated into gametes to continue the parasite life cycle in the mosquito midgut. Both persistence of gametocytes in the blood and their activation into gametes are tightly regulated by phospho-signaling. While the serine-threonine phosphatase PfPP1 is an essential enzyme for asexual blood stage parasite proliferation, its role during transmission of sexual stages remains elusive. Here, we employed a conditional depletion strategy to conduct a functional analysis of PfPP1 during gametocyte development, gamete formation, and transmission to mosquitoes. We s

SUBMITTER: Royer L 

PROVIDER: S-EPMC12421956 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature